Researchers at Edith Cowan University’s (ECU) Centre for Precision Health have made a groundbreaking discovery, revealing a significant genetic connection between Alzheimer’s disease (AD) and several coronary artery disease (CAD) related disorders. This research may offer new opportunities to improve health outcomes for two major causes of death in Australia.
SHARED GENETIC ORIGINS
The study identified that factors related to heart disease, including angina, arteriosclerosis, ischemic heart disease, myocardial infarction, and CAD, as well as lipid classes like cholesterol, triglycerides, and both high-density lipoproteins (HDL) and low-density lipoproteins (LDL), share similar genetic origins with AD.
This suggests that the same genes may play a role in or be associated with these conditions.
INSIGHTS FROM GENETIC RESEARCH
Lead researcher and Centre for Precision Health PhD candidate, Artika Kirby, explained, “While there is considerable observational evidence linking these conditions, the biological mechanisms of AD and its relationship with lipids and CAD traits are still not well understood.”
“Our study used genetic methods to explore these complex relationships, providing new insights into their shared biological foundations. I am hopeful that these findings will pave the way for research that could enhance lives globally.”
ADVANCED STATISTICAL GENETICS APPROACHES
Professor Simon Laws, Director of the Centre for Precision Health and co-supervisor of the study, praised the research. “The Centre for Precision Health’s use of advanced statistical genetics methods is crucial for understanding the connections between major health conditions. This study highlights the effectiveness of this approach.”
IMPACT ON HEALTH OUTCOMES
Dementia, with AD as its leading cause, and CAD are among the top causes of death in Australia. The study suggests that the link between these conditions might be deeper than previously thought, with CAD potentially accelerating cognitive decline and increasing the risk of dementia. Research indicates that CAD patients have a 26% higher relative risk of developing dementia.
POTENTIAL SHARED RISK FACTORS
The connection between CAD and AD could reflect shared risk factors such as dyslipidaemia and inflammation. Lipid disorders and CAD are significant risk factors for AD, suggesting a possible genetic predisposition linking all these factors.
FUTURE RESEARCH DIRECTIONS
Dr. Emmanuel Adewuyi, NHMRC Emerging Leadership Fellow and project co-supervisor, commented, “Our genetic approach has revealed novel insights into how AD and coronary heart disease are linked. These insights could lead to improvements in patient care and outcomes, not only in Australia but globally.”
GLOBAL IMPLICATIONS
The study’s findings may have broad implications for understanding and addressing both AD and CAD, potentially leading to new strategies for prevention and treatment of these critical health issues.
This significant research from ECU highlights the genetic connections between Alzheimer’s disease and coronary artery disorders, offering new perspectives on their shared mechanisms. As the study progresses, it holds promise for advancing patient care and health outcomes worldwide.
