New research from the University of Southern Denmark sheds light on the potential therapeutic use of psilocybin, the active compound in psychedelic mushrooms, through micro dosing. While psilocybin has long been recognized for its classic psychedelic properties and its role in treating psychiatric disorders, this study explores the effects of small, repeated doses of psilocybin, commonly referred to as ‘micro dosing.’
In this research, Associate Professor Mikael Palner and PhD student Kat Kiilerich from the University of Southern Denmark’s Research Unit for Clinical Physiology and Nuclear Medicine focused on the impact of these low doses of psilocybin in rats.
INCREASED RESILIENCE
The findings were published in Nature – Molecular Psychiatry, and they reveal that rats tolerated repeated low doses of psilocybin well and did not exhibit reduced pleasure, anxiety, or altered locomotor activity. Most notably, the rats displayed increased resilience to stress and less compulsive behaviour. The researchers also observed an increase in the number of connections to the thalamus region of the brain, which plays a crucial role in decision-making and processing concerns.
These changes in brain connectivity may contribute to enhanced resilience to stress factors and potentially explain the reported positive effects on well-being from small doses of psychedelic mushrooms. The study provides a validated method for further research into the effects of micro dosing and supports anecdotal reports of its therapeutic benefits.
NEW DOOR OPENS
This research opens the door to new possibilities in the treatment of various mental disorders. Given the rising interest in micro dosing and the legalization of psilocybin for therapeutic use in countries like the Netherlands, Australia, the USA, and Canada, it is vital to understand the effects and potential side effects of these substances.
Associate Professor Mikael Palner, who led this study, embarked on this research journey inspired by the surge of self-improvement practices, particularly in Silicon Valley. He aims to advance our understanding of the effects of micro dosing, contributing to both the field of science and society’s well-being. This research offers hope for those seeking alternative approaches to addressing mental health challenges and enhancing overall mental well-being.
