A new study led by experts at the University of Nottingham has raised concerns about the repeated use of paracetamol (acetaminophen) in adults aged 65 and over. The research, published in Arthritis Care and Research, found that continuous paracetamol use may increase the risk of gastrointestinal, cardiovascular, and renal complications.
The study analyzed the health records of 180,483 individuals aged 65 and above. These individuals were repeatedly prescribed paracetamol over a period of time. The findings revealed a significant association between frequent paracetamol use and various health risks.
PARACETAMOL’S LONG-STANDING REPUTATION AS A SAFE PAIN RELIEVER
Paracetamol has long been regarded as a safe treatment for osteoarthritis pain. It is effective as a first-line choice, especially among older adults who are often at a higher risk of adverse drug reactions. Yet, this new research challenges the drug’s safety profile, especially for long-term use in older individuals.
Weiya Zhang, lead researcher at the University of Nottingham’s School of Medicine, noted that paracetamol is commonly recommended for osteoarthritis due to its perceived safety. Nevertheless, it provides minimal pain relief. The small relief may not outweigh the potential risks, particularly for the elderly.
STUDY DETAILS AND FINDINGS
The study used health records from the UK’s National Health Service (NHS). It compared the health outcomes of people aged 65 and above who had been prescribed paracetamol repeatedly. This included more than two prescriptions within six months. These were compared with those who had never received repeated prescriptions.
- Study Group: 180,483 individuals, average age 75, who received repeated paracetamol prescriptions between 1998 and 2018.
- Control Group: 402,478 individuals of similar age, who had never been prescribed paracetamol repeatedly.
The analysis revealed an increased incidence of renal, gastrointestinal, and cardiovascular complications in those who took repeated doses.
IMPLICATIONS FOR PAIN MANAGEMENT IN OLDER ADULTS
Researchers identified potential risks in the study. They suggest that long-term use of paracetamol for conditions like osteoarthritis in older adults should be carefully reconsidered. This medicine is often recommended due to its mild pain-relieving effects. But, the research highlights the need for substitute pain management strategies.
Zhang emphasized that further research is needed to confirm the findings. The results raise important questions about the safety of paracetamol. This is particularly relevant for older individuals with chronic conditions.