Liver cancer risks linked to diet are well known. Red meat, alcohol, and processed foods raise concerns. But what about lung cancer? A new study by University of Florida Health researchers uncovers how poor diet may increase lung cancer risk. The study, funded by the National Institutes of Health, also involved the University of Kentucky’s Markey Cancer Center.
“Lung cancer isn’t traditionally considered a diet-related disease,” said Dr. Ramon Sun, associate professor at UF. “For pancreatic or liver cancer, yes. But lungcancer? That’s rarely discussed.”
Yet, recent findings suggest otherwise. Dr. Matthew Gentry, a UF College of Medicine professor, said this is the first major study. It links diet and lungcancer at an NCI-designated center.
IMPACT OF GLYCOGEN ON CANCER GROWTH
Researchers used an advanced spatial metabolomics platform developed by Sun in 2020. This technology allows scientists to map molecular patterns in diseases with unparalleled detail.
The study focused on lung adenocarcinoma, the most common lung cancer worldwide. It also drew insights from Lafora disease, a rare neurological condition that causes severe epilepsy and early death.
GLYCOGEN: A HIDDEN FUEL FOR TUMORS
Lafora disease involves excess glycogen, a sugar storage molecule. High glycogen levels have been observed in various cancers, including lungcancer.
Lab and computer models revealed that glycogen acts as an oncogenic metabolite. In other words, it fuels cancer growth. “It’s like a giant lollipop for cancer’s sweet tooth,” Sun explained.
Mice fed a high-fat, high-fructose Western diet showed higher glycogen levels and faster tumor growth. When glycogen levels dropped, tumor growth slowed. The study confirms that a Western diet significantly contributes to lungcancer progression.
WESTERN DIETS
A high-fat, high-fructose diet raises glycogen levels, fueling cancer cells. Researchers found that glycogen levels strongly predict tumor growth and survival rates in such patients.
While this link is new for lung cancer, nutrition’s role in cancer prevention is well established.
RETHINKING LUNG CANCER PREVENTION
Dr. Sun believes lung cancer prevention should include dietary awareness, much like anti-smoking campaigns. “We need public education and policies promoting healthier diets,” he stressed.
CAN DIET-BASED TREATMENTS HELP?
An encouraging finding is that glycogen-targeting drugs already exist. Originally developed for Lafora disease, these treatments could potentially be repurposed for lungcancer.
HOW TO REDUCE LUNG CANCER RISK THROUGH DIET
Dr. Gentry offers simple advice: “Eat nutrient-rich foods, stay active, and limit alcohol. These lifestyle choices play a major role in preventing lungcancer.”
Lung cancer prevention must extend beyond smoking cessation. A high-fat, high-fructose diet fuels tumor growth. This study highlights the urgent need for dietary awareness in prevention.
Making healthier food choices could be a powerful tool in reducing the risk and improving overall health.