Toxic Particles Get Directly To Brain

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The toxic particles that we breathe in through polluted air directly gets into the brain from the lungs, according to a new study. The Scientists from the University of Birmingham and research institutions in China discovered a possible direct pathway used by various inhaled fine particles through blood circulation with indications that, once there, the particles stay longer in the brain than in other main metabolic organs.

The findings are published in PNAS.

The scientists claimed that they came across several fine particles in human cerebrospinal fluids of patients who had experienced brain disorders. This showed that toxic particulate substances end up in the brain.

Co-author Professor Iseult Lynch (University of Birmingham) said: “There are gaps in our knowledge around the harmful effects of airborne fine particles on the central nervous system. This work sheds new light on the link between inhaling particles and how they subsequently move around the body.

“The data suggests that up to eight times the number of fine particles may reach the brain by travelling, via the bloodstream, from the lungs than pass directly via the nose – adding new evidence on the relationship between air pollution and detrimental effects of such particles on the brain,” the researcher said.  


Air pollution contains a cocktail of toxic components. However, particulate matter (PM, especially ambient fine particles such as PM, and PM0,1), are the most concerning in terms of causing detrimental health effects. Ultrafine particles, in particular, are able to escape the body’s protective systems, including sentinel immune cells and biological barriers. Recent evidence has revealed a strong link between high levels of air pollution and marked neuro inflammation, Alzheimer’s-like changes and cognitive problems in older people and even in children. The scientists discovered that inhaled particles can enter the bloodstream after crossing the air-blood barrier – eventually reaching the brain, and leading to damage of the brain-blood barrier and surrounding tissues as they do so. Once in the brain, the particles were hard to clear and were retained for longer than in other organs. The findings offer new evidence in proving the risks from particulate pollution to the central nervous system.


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