Discrimination During Pregnancy Linked to Infant Brain Connectivity

Pregnant women’s experiences of discrimination and acculturation can impact the brain circuitry of their infants, independent of general stress and depression, according to a recent study by Yale and Columbia University. The research, published in Neuropsychopharmacology, examined 165 pregnant individuals and conducted magnetic resonance imaging (MRI) on 38 infants after birth. The findings suggest that discrimination and acculturation have distinct effects on brain connectivity, particularly weakening connectivity between the amygdala and prefrontal cortex in infants whose parents experienced discrimination during pregnancy.


Distinct Experiences: Discrimination and acculturation were identified as distinct from general stress and depression through data analysis that separated various questionnaire measures into groups based on similarity.

Impact on Connectivity: Children of parents who reported discrimination during pregnancy exhibited weaker connectivity between the amygdala and prefrontal cortex, aligning with patterns seen in individuals affected by early-life adversity.

Unique Effects: The study emphasizes the uniqueness of the impact of discrimination and acculturation on the brain, calling for further research to understand the biological mechanisms behind these effects.

MRI Analysis: The study assessed brain connectivity in infants, focusing on the amygdala, associated with emotional processing, and its connectivity with the prefrontal cortex, linked to higher-order functioning.


The findings highlight the need for a better understanding of the distinct effects of discrimination and acculturation on brain development in infants. The researchers emphasize the importance of investigating whether similar effects are observed in other populations and delving into the biological mechanisms that transmit experiences of adversity from parents to offspring.

The study underscores the significance of recognizing discrimination and acculturation as distinct factors influencing infant brain connectivity and calls for continued research to unravel the underlying mechanisms and potential impacts on diverse populations.


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