Dementia Improvement in Men and Women

Stress and Impact on Memory

Physical and mental activity helps in improving skills and delaying dementia. But does that differ in men and women? A new study shows that physical and mental activities vary for men and women.

The study published in the online issue of Neurology  (medical journal of the American Academy of Neurology), looked into the effects of various physical and mental activities, including reading, going to classes, or playing cards or games, on cognitive reserve in the areas of thinking speed and memory. Cognitive reserve is the buffer that occurs when people have strong thinking skills even when their brains show signs of the underlying changes associated with cognitive impairment and dementia.

Author Judy Pa of the University of California, San Diego, said that they found that greater physical activity was associated with greater thinking speed reserve in women, but not in men. “Taking part in more mental activities was associated with greater thinking speed reserve for both men and women,” the author said.


In the study, the authors looked at 758 people with an average age of 76. When some had no thinking or memory problems, some had mild cognitive impairment, and some others had dementia. The participants had brain scans and took thinking speed and memory tests. To calculate cognitive reserve, people’s thinking tests scores were compared against the changes in the brain associated with dementia, such as the total volume of the hippocampus, a key brain region impacted by Alzheimer’s disease.

The participants were asked about their usual weekly physical activity. For mental activity, they were asked whether they participated in three types of activities in the past 13 months: reading magazines, newspapers or books; going to classes; and playing cards, games or bingo. They were given one point for each type of activity, for a maximum of three points.

For mental activity, participants averaged 1.4 points. For physical activity, participants took part in an average of at least 15 minutes per week of activities that elevate heart rates such as brisk walking and biking.

“As we have arguably few-to-no effective treatments for Alzheimer’s disease, prevention is crucial. An ounce of prevention is worth a pound of treatment,” Pa said. “To know that people could potentially improve their cognitive reserve by taking simple steps such as going to classes at the community center, playing bingo with their friends or spending more time walking or gardening is very exciting.”

Pa said that based on the effect sizes seen in the study, a doubling of the amount of physical activity would be equivalent to an estimated 2.75 fewer years of aging when it comes to women’s processing speed in their thinking skills.

Researchers also looked at whether the relationship between physical and mental activities and cognitive reserve was affected by the gene that carries the strongest risk for Alzheimer’s, called APOE e4. They found that for women, having the gene lessens the effects of the beneficial relationship between physical and mental activities and cognitive reserve.

The National Institute on Aging and the National Center for Advancing Translational Sciences supported the study.


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