In a breakthrough development in the treatment of Alzheimer’s disease, the scientists in India developed a small molecule that disrupts the mechanism through which neurons become dysfunctional in Alzheimer’s disease.
They claim that these molecules could be a potential drug candidate to halt or cure the leading cause of dementia In the Alzheimer’s brain, abnormal levels of naturally forming protein clump together to form plaques that collect between neurons and disrupt cell function. This is caused by production and deposition of the amyloid peptide that accumulates in the central nervous system. The multifactorial nature of Alzheimer’s disease attributed to multifaceted amyloid toxicity has kept researchers from developing effective treatment.
A team of scientists led by Professor T. Govindaraju from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) designed and synthesized a set of novel small molecules and identified a lead candidate which they found could reduce the toxicity of Amyloid Beta (toxicity. Advanced Therapeutics published the findings.
Mice brain affected with Alzheimer’s disease when treated with TGR63 showed a significant reduction of amyloid deposits, validating its therapeutic efficacy, the researchers said. The mice also showed reduction of learning deficiency, memory impairment, and cognitive decline as revealed by distinct behavioural tests.